Original Toy Company Dantoy Crocodile Rocker

Made from top grade raw materials by Dantoy of Denmark..Do you want Original Toy Company Dantoy Crocodile Rocker with Best Prices? Got it! . We have deals for Original Toy Company Dantoy Crocodile Rocker . Read many useful reviews and Prices Comparision with limited time offer. You will recieve a Best Rate Or Free Shipping for Original Toy Company Dantoy Crocodile Rocker . This product posted on Original Toy Company Dantoy Crocodile Rocker Source from Original Toy Company Dantoy Crocodile Rocker

HMB Oddity - Muscle Building Supplements Research

Glucose

Glucose is ordinary blood sugar. In the diet it comes from the breakdown of starch (a glucose polymer) and of table sugar (a disaccharide of glucose and fructose) and other disaccharides (e.g., maltose, lactose). Because it is standard blood sugar, muscle and other tissues have receptors for it, co-transporters that help get it into cells, and special enzymes for breaking it down throughout the body to harvest metabolic energy from it.

One of its actions seems to involve an interaction with L-leucine and probably other BCAAs for getting fuel into muscle tissue. It seems logical that HMB (beta-hydroxy-beta-methylbutyrate), which a metabolite of L-leucine and is the best of the muscle building supplements on the market, also has a potential role in fueling muscle cells.

With that brief background, you may understand why the recent research study that I cite below was directed at finding out more about the potentially interdependent roles of HMB and glucose in a combined supplement formula.

Note that the formula I describe there is based on solid research, and it also involves a boosting effect from glucose.

Odd Research

You may not realize how expensive it is to conduct a research study involving human subjects. Well, it is very expensive. That is why two consistent flaws characterize most human studies: 1) too few subjects; and, 2) they do not do dose-dependent evaluations (i.e., how much of what causes what ... I hope that is at least a little clear). They use a small group of people and one dosage level of the treatment variable.

This is the full citation of the study in question:

Vukovich MD, Slater G, Macchi MB, Turner MJ, Fallon K, Boston T, Rathmacher J. beta-hydroxy-beta-methylbutyrate (HMB) kinetics and the influence of glucose ingestion in humans. J Nutr Biochem. 2001 Nov;12(11):631-639.

Three treatment protocols were: 1) modified glucose tolerance test (75 g glucose) (GLU), 2) oral ingestion of 3 g of HMB with water (HMB), and 3) ingestion of 3 g of HMB with 75 g of glucose (HMB+GLU).

75 Grams of Glucose!

That is a lot of glucose. If I weigh out a heaping teaspoon of glucose powder in my kitchen, it comes to 7.8 grams. Picture this: 75 grams is more than 9.5 teaspoons.

Furthermore, the ratio of glucose to HMB is 25:1. That is a lot of glucose.

The results, however, were good regarding the peak amount of HMB with glucose, and the time it remains in plasma (expressed as its half-life).

Nevertheless, the protocol used just too much glucose. (Compare the amount here, 75 grams, with the amount of sugar in a 12 oz can of Coca Cola, which is about 45 grams - wow!)

I guess I have made myself clear about how astounded I am about the huge amount of glucose used in this study. Without dose-dependent evaluation, we have no idea whether that amount is necessary to elicit the reported results. It may be overkill and it may not.

I tend to think it is overkill, though. That is partly because similar studies using creatine, which also influences and is influenced by glucose when taken orally, show a beneficial ratio of about 5:1 (glucose to creatine).
Ah, the oddities of scientific research!

HMB Best Of Muscle Building Supplements For Senior Fitness

Muscle Building Supplements for Seniors

Very few muscle building supplements are developed with seniors in mind. Bodybuilding sites focus on the young and overly muscled. Experts also promote supplements as if they are effective regardless of age. The often ignored issue is the age-related limitations on supplements.

This issue also seems to be the case with the increasingly popular use of branched-chain amino acids (BCAAs) as muscle building supplements. However, a key metabolite of leucine, which is one of the BCAAs, is turning out to be an exception. This metabolite, beta-hydroxy-beta-methylbutyrate (HMB) does, indeed, have a comparable effect for building muscle mass in older vs. younger adults.

Key Research on HMB

The following key study is one of the very few that entail senior subjects. It addresses the effects of HMB in 70-year old adults. Here are the reference details of the study:

Vukovich MD, Stubbs NB, Bohlken RM. Body composition in 70-year-old adults responds to dietary beta-hydroxy-beta-methylbutyrate similarly to that of young adults. J Nutr. 2001 Jul;131(7):2049-52.

Fifteen men and sixteen women, average age 70 years, were randomly assigned in a double-blind study to receive either capsules containing a placebo or HMB at 3 grams per day for 8 weeks. At the end of 8 weeks, HMB supplementation tended to increase fat-free mass gain, increased the percentage of body fat loss. CT scans also indicated a greater decrease in the percentage of body fat with HMB supplementation.

The authors concluded that changes in body composition can be accomplished in 70-y-old adults participating in a strength training program, as previously demonstrated in young adults, when HMB is supplemented daily.

Key Age Comparison for Senior Fitness

The authors of this study provided a comparison that is often missing in published studies. It is one thing to say that results have been comparable across several studies. However, these authors provided an analysis of several other studies and showed that results with 70-year-old adults were comparable to studies of subjects in their 20s.

All of the studies in this comparison showed a net weekly increase in percent Fat Free Mass with HMB supplements. The current study shows that 70-year olds might even expect a little bit better than average increase in comparison with the 20-somethings.

That, dear readers, is a rarity regarding aging. And quite a pleasant one for me as I approach that milestone in the next few years.

Muscle Building Supplements For Senior Fitness

Good Muscle Building Supplements Hard to Find for Senior Fitness

Muscle mass drops quickly after about age 50. Muscle loss becomes a health concern starting after age 60. Unfortunately, the vast majority of supplements for enhancing lean body mass are directed at younger people. Research studies on their use for seniors is either absent or shows weak results.

Typical examples include growth hormone (hGH) secretagogues, supplements that increase hGH release from the pituituary gland. HGH spikes are very valuable for counteracting muscle loss. The most commonly researched supplement for this purpose is L-arginine. The bad news that I discovered for my age group (mid-60s), though, is that it fails for us seniors.

The best that commercial industry has to offer is a product called Ensure Muscle Health. I wouldn't put that junk in my body on a dare. Taking a quick look at the Nutrition Facts shows that this is mostly sugar water - the first two ingredients are water and sugar - with a few grams of protein, mostly from casein, the cheapest protein on the market. To be at least a little positive, you get 13 grams of protein to go with your 22 grams of sugar (part of 32 grams of carbohydrate overall).

That is way too much sugar! For comparison, one small, 8 oz bottle provides almost 2.5 times the amount of sugar as a 12 oz can of Coca Cola. Wow!

If anything, the best ingredient in this product for building or retaining muscle mass is hidden in the ingredients list: beta-hydroxy-beta-methylbutyrate (aka, HMB). You know what that is, right? Right...it's a common supplement that everyone knows about - NOT. This is actually a fantastic ingredient for muscle building supplements, especially for senior fitness, which I have written about earlier.

The good news about HMB is twofold: 1) It is available in products other than Ensure Muscle Health; and, 2) It can be combined with two common amino acids, in reasonable doses, that have been shown to provide significant benefits in as few as 12 weeks. And it works in some the weakest seniors in our 'mature' population: elderly women.

Great News for Senior Men and Women

My view is that, if something works well in elderly women, even in the absence of an exercise program, then it certainly will help me. Here are full reference citation details of the study in questions:

Flakoll P, Sharp R, Baier S, Levenhagen D, Carr C, Nissen S. Effect of beta-hydroxy-beta-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women. Nutrition. 2004 May;20(5):445-51.

The study protocol included women of average age 76.7 years who were randomized to receive either a placebo or a treatment with 2 g beta-hydroxy-beta-methylbutyrate (HMB), 5 g arginine, and 1.5 g lysine daily.

After 12 wk, there was a 17% improvement in the "get-up-and-go" functionality test in the treatment group but no change in the placebo group. Improvements in the treatment group were also seen increased limb circumference, leg strength, handgrip strength and positive trends in fat-free mass. In addition, whole-body protein synthesis increased approximately 20% in the treatment group as opposed to the placebo group.

The authors concluded that daily supplementation of beta-hydroxy-beta-methylbutyrate, arginine, and lysine for 12 weeks positively alters measurements of functionality, strength, fat-free mass, and protein synthesis, suggesting that the strategy of targeted nutrition has the ability to affect muscle health in elderly women.

The nice thing about research studies like this is that, even if the scientific jargon is a little complicated, the conclusions are very clear. Let me also point out that the daily dosages used in this study correspond to reasonable amounts of these supplements: 2 grams of HMB, 5 grams of arginine, and 1.5 grams of lysine. In fact, supplements are now widely available that provide the right amount of HMB, and supplements have been widely available for a long time that provide the right amounts of arginine and lysine.

It may seem as though the benefits are a little understated here. As a career-long research scientist, I will just say that I'm not really into marketing hype. I think the research speaks for itself. A more telling comment is this: I am sufficiently impressed by this study that I have added these ingredients to my own daily supplement regimen. I recommend them for everyone, especially for us 'mature' folks who want (and expect) to stay fit for many years to come.



Posterous theme by Cory Watilo